My friend, Jim Harmer (more of a trusted acquaintance) has ferreted out a little known feature of PhotoShop that is a major find for the average vacation shooter.
Take a bunch of fixed, tripodded shots only a few seconds apart of the same scene, load them into Photoshop, and this little known feature will magically remove anything that was a moving object (like walking humans). I looked up the feature in my CS5; sure enough, it was there all the time. It even has a cool wizard that walks you through and even loads the right pics for you.
Click on the photos here to see Jim's article